Journal of Liver Cancer

Sinn, Dong Hyun

2 Articles

A Case of Hepatocellular Carcinoma Treated by Proton Beam Therapy as 1st Choice: Oh, Jinmyeong , Sinn, Dong Hyun , Seong, Gyeol , Chung, Hye Gyo , Heo, Chanmi , Yu, Jeongil , Park, Hee Chul; J Liver Cancer. 2018;18(1):80-85. Published online March 31, 2018; DOI: https://doi.org/10.17998/jlc.18.1.80

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Although first-line treatment option for single, small sized hepatocellular carcinoma in patients with preserved liver function and good performance status is resection or ablation, sometimes these modalities cannot be applied for variable reasons. For them, alternative options such as transarterial chemoeombolization, ethanol injection, and external radiation therapy can be considered, with variable success rates. Herein, we describe 45 year-old male who presented with a single small tumor located at caudate lobe. After multi-disciplinary discussion, the patient was treated with proton beam therapy, which resulted in favorable treatment outcome.

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Carbon ion radiotherapy for patients with hepatocellular carcinoma in the caudate lobe
Shohei Okazaki, Kei Shibuya, Shintaro Shiba, Masahiko Okamoto, Yuhei Miyasaka, Naoto Osu, Motohiro Kawashima, Satoru Kakizaki, Kenichiro Araki, Ken Shirabe, Tatsuya Ohno
Hepatology Research.2021; 51(3): 303. CrossRef

Noninvasive Diagnostic Criteria of the Revised 2014 the Korean Liver Cancer Study Group and the National Cancer Center Guideline for Subcentimetersized Hepatocellular Carcinoma: Is It Too Strict?: Kim, Nam Joong , Sinn, Dong Hyun , Kang, Wonseok , Paik, Yong Han , Choi, Moon Seok , Lee, Joon Hyeok , Koh, Kwang Cheol , Paik, Seung Woon , Gwak, Geum Youn; J Liver Cancer. 2018;18(1):44-50. Published online March 31, 2018; DOI: https://doi.org/10.17998/jlc.18.1.44

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Background/Aim
s: Noninvasive diagnostic criteria for hepatocellular carcinoma (HCC) differ between guidelines, especially for subcentimeter-sized nodules. This study aimed to analyze clinical and radiological characteristics of subcentimeter-sized HCC, and assess the validity of noninvasive diagnostic criteria of the revised 2014 the Korean Liver Cancer Study Group and the National Cancer Center (KLCSG-NCC) guideline for subcentimeter-sized HCC. Methods: A total of 33 consecutive patients (median age, 58.6 years; men, 60.6%; hepatitis B virus-infected, 87.9%) who were diagnosed with HCC between January 2009 and December 2013 and had a maximum tumor diameter less than 1 cm were retrospectively included. Results: Among 33 subcentimeter-sized HCC cases, 6 cases were histologically proven and the remaining 27 patients were diagnosed by radiologically and/or serologically. Initial detection modality was dynamic contrast-enhanced computed tomography (CT) (66.7%, 22/33) or dynamic contrast-enhanced magnetic resonance imaging (MRI) (33.3% 11/33). No case was identified by surveillance ultrasonography. Typical radiological feature of HCC, which is arterial enhancement with delayed washout, was present in 51.7% (15/29 patients) in dynamic contrast-enhanced CT, and 90.9% (30/33 patients) in dynamic contrast-enhanced MRI. When these 33 cases were re-assessed by the revised 2014 KLCSG-NCC guideline, no one has fulfilled the noninvasive diagnostic criteria. Conclusions: None of the cases that were diagnosed as subcentimeter-sized HCC including histologically confirmed cases did not fulfill the noninvasive diagnostic criteria of the revised 2014 KLCSG-NCC guideline. Refinement of the current noninvasive diagnostic criteria for subcentimeter-sized HCC may be required.

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Clinical practice guideline and real-life practice in hepatocellular carcinoma: A Korean perspective
Myung Ji Goh, Dong Hyun Sinn, Jong Man Kim, Min Woo Lee, Dong Ho Hyun, Jeong Il Yu, Jung Yong Hong, Moon Seok Choi
Clinical and Molecular Hepatology.2023; 29(2): 197. CrossRef